The developed methodology improves our understanding of patient-specific drug pharmacokinetics towards personalized drug administration.Ĭancer management is challenged by large inter- and intra-patient variabilities in both disease progression and response to treatments. The whole framework achieved a very good fit to data and allowed quantifying inter-patient variability in PK parameters and linking them to potential clinical biomarkers via patient clustering. Physiologically-based PK models of the three drugs were then linked to the pump-to-patient model. This mathematical model was then used to suggest improved profiles in order to minimise error and optimise delivery. A pump-to-patient model was designed and revealed significant inconsistencies between intended drug profiles and actual plasma concentrations. Here, PK data from cancer patient receiving irinotecan, oxaliplatin and 5-fluorouracil into the hepatic artery via an infusion pump was mathematically investigated. Author summary Accuracy and safety of infusion pumps remain a critical issue in the clinics and the development of accurate mathematical models to optimize drug administration though such devices has a key part to play in the advancement of precision medicine.
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